Purity of islet preparations and 5-year metabolic outcome of allogenic islet transplantation
نویسندگان
چکیده
منابع مشابه
Introducing a New Experimental Islet Transplantation Model using Biomimetic Hydrogel and a Simple High Yield Islet Isolation Technique
Background: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus (T1DM). This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functi...
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The initial step in successful islet transplantation is procurement of healthy donor islets. Given the limited number of donor pancreata selected for islet isolation and that islets from multiple donors are typically required to obtain insulin independence, it is critical to improve pancreas procurement rates and yield of islets for transplantation. Islets are delicate microorgans that are susc...
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BACKGROUND Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of recipients remains insulin-independent in the following years. We tested the hypothesis that allograft rejection and recurrent autoimmunity contribute to this progressive loss of islet allograft function. METHODOLOGY/PRINCIPAL FINDINGS Twenty-one T1D patients received cultured islet cell grafts prepar...
متن کاملTransplantation and islet topics.
Posttransplantation diabetes The American Society of Transplantation (www.a-s-t.org) held a symposium at the June ADA meeting addressing the importance of diabetes following transplantation (1). Martha Pavlakis (Boston, MA) introduced the symposium, pointing out the importance of “long-term management, now that our focus is no longer [merely] getting the patient to survive 1 year.” Among the ri...
متن کاملIslet and Pancreas Transplantation
Islet allotransplantation for patients with brittle type 1 diabetes mellitus (T1DM) is a minimally invasive and relatively safe procedure that can induce sustained, normalized glucose control and restore C-peptide secretion, with reduction of hypoglycemic episodes, stabilization or delay of chronic complications, and better quality of life. Current immunosuppressive protocols have significantly...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2017
ISSN: 1600-6135
DOI: 10.1111/ajt.14514